View source for 1xp3


==Crystal Structure of Endonuclease IV (BA4508) from Bacillus anthracis at 2.57A Resolution.==
<StructureSection load='1xp3' size='340' side='right'caption='[[1xp3]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1xp3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XP3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xp3 OCA], [https://pdbe.org/1xp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xp3 RCSB], [https://www.ebi.ac.uk/pdbsum/1xp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xp3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/END4_BACAN END4_BACAN] Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xp/1xp3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xp3 ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Endonuclease 3D structures|Endonuclease 3D structures]]
__TOC__
</StructureSection>
[[Category: Bacillus anthracis]]
[[Category: Large Structures]]
[[Category: Blagova EV]]
[[Category: Brannigan JA]]
[[Category: Fogg MJ]]
[[Category: Levdikov VM]]
[[Category: Wilkinson AJ]]
[[Category: Wilson KS]]