View source for 1wwh


==Crystal structure of the MPPN domain of mouse Nup35==
<StructureSection load='1wwh' size='340' side='right'caption='[[1wwh]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1wwh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WWH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wwh OCA], [https://pdbe.org/1wwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wwh RCSB], [https://www.ebi.ac.uk/pdbsum/1wwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wwh ProSAT], [https://www.topsan.org/Proteins/RSGI/1wwh TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NUP35_MOUSE NUP35_MOUSE] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/1wwh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wwh ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Hamana H]]
[[Category: Handa N]]
[[Category: Kukimoto M]]
[[Category: Murayama K]]
[[Category: Shirouzu M]]
[[Category: Takemoto C]]
[[Category: Terada T]]
[[Category: Uchikubo T]]
[[Category: Yokoyama S]]