View source for 1whg


==Solution structure of the CAP-Gly domain in mouse tubulin specific chaperone B==
<StructureSection load='1whg' size='340' side='right'caption='[[1whg]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1whg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whg OCA], [https://pdbe.org/1whg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whg RCSB], [https://www.ebi.ac.uk/pdbsum/1whg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whg ProSAT], [https://www.topsan.org/Proteins/RSGI/1whg TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TBCB_MOUSE TBCB_MOUSE] Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (By similarity). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.<ref>PMID:17184771</ref> <ref>PMID:17217416</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/1whg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1whg ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Saito K]]
[[Category: Yokoyama S]]