View source for 1ful


==SOLUTION STRUCTURE OF AN RGD PEPTIDE ISOMER-B==
<StructureSection load='1ful' size='340' side='right'caption='[[1ful]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ful]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FUL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 19 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ful FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ful OCA], [https://pdbe.org/1ful PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ful RCSB], [https://www.ebi.ac.uk/pdbsum/1ful PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ful ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the activities of the matrix proteins. Depending on the context of the RGD sequence, an RGD-containing peptide may bind to all of the RGD-directed integrins, to a few, or to only a single one. We have previously isolated from a phage-displayed peptide library a cyclic peptide that binds avidly to the alpha(v)beta3 and alpha(v)beta5 integrins but does not bind to other closely related integrins. This peptide, ACDCRGDCFCG, exists in two natural configurations depending on internal disulfide bonding. The peptide with the 1-4; 2-3 disulfide bond arrangement accounts for most of the alpha(v) integrin binding activity, whereas the 1-3; 2-4 peptide is about 10-fold less potent. Solution structure analysis by nuclear magnetic resonance reveals an entirely different presentation of the RGD motif in the two isomers of RGD-4C. These results provide new insight into the ligand recognition specificity of integrins.

Solution structures and integrin binding activities of an RGD peptide with two isomers.,Assa-Munt N, Jia X, Laakkonen P, Ruoslahti E Biochemistry. 2001 Feb 27;40(8):2373-8. PMID:11327857<ref>PMID:11327857</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1ful" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Assa-Munt N]]
[[Category: Jia X]]
[[Category: Laakkonen P]]
[[Category: Ruoslahti E]]