View source for 2cf5

[[Image:2cf5.gif|left|200px]]<br />
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'''CRYSTAL STRUCTURES OF THE ARABIDOPSIS CINNAMYL ALCOHOL DEHYDROGENASES, ATCAD5'''<br />

==Overview==
The cinnamyl alcohol dehydrogenase (CAD) multigene family in planta, encodes proteins catalyzing the reductions of various phenylpropenyl, aldehyde derivatives in a substrate versatile manner, and whose metabolic, products are the precursors of structural lignins, health-related lignans, and various other metabolites. In Arabidopsis thaliana, the two isoforms, AtCAD5 and AtCAD4, are the catalytically most active being viewed as, mainly involved in the formation of guaiacyl/syringyl lignins. In this, study, we determined the crystal structures of AtCAD5 in the apo-form and, as a binary complex with NADP+, respectively, and modeled that of AtCAD4., Both AtCAD5 and AtCAD4 are dimers with two zinc ions per subunit and, belong to the Zn-dependent medium chain dehydrogenase/reductase (MDR), ... [[http://ispc.weizmann.ac.il/pmbin/getpm?16633561 (full description)]]

==About this Structure==
2CF5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.195 1.1.1.195]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CF5 OCA]]. 

==Reference==
Crystal structures and catalytic mechanism of the Arabidopsis cinnamyl alcohol dehydrogenases AtCAD5 and AtCAD4., Youn B, Camacho R, Moinuddin SG, Lee C, Davin LB, Lewis NG, Kang C, Org Biomol Chem. 2006 May 7;4(9):1687-97. Epub 2006 Apr 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16633561 16633561]
[[Category: Arabidopsis thaliana]]
[[Category: Single protein]]
[[Category: Camacho, R.]]
[[Category: Davin, L.]]
[[Category: Kang, C.]]
[[Category: Lee, C.]]
[[Category: Lewis, N.]]
[[Category: Moinuddin, S.]]
[[Category: Youn, B.]]
[[Category: ZN]]
[[Category: lignin biosynthesis]]
[[Category: metal-binding]]
[[Category: nadp]]
[[Category: oxidoreductase]]
[[Category: zinc]]

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