View source for 1tjs

[[Image:1tjs.gif|left|200px]]<br />
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'''E. COLI THYMIDYLATE SYNTHASE'''<br />

==Overview==
BACKGROUND: Enzymes have evolved to recognise their target substrates with, exquisite selectivity and specificity. Whether fragments of the, substrate--perhaps never available to the evolving enzyme--are bound in, the same manner as the parent substrate addresses the fundamental basis of, specificity. An understanding of the relative contributions of individual, portions of ligand molecules to the enzyme-binding interaction may offer, considerable insight into the principles of substrate recognition., RESULTS: We report 12 crystal structures of Escherichia coli thymidylate, synthase in complexes with available fragments of the substrate (dUMP), both with and without the presence of a cofactor analogue. The structures, display considerable fidelity of binding mode and interactions. These, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9687366 (full description)]]

==About this Structure==
1TJS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with PO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Transferase Transferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]]. Structure known Active Site: ACT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TJS OCA]]. 

==Reference==
The additivity of substrate fragments in enzyme-ligand binding., Stout TJ, Sage CR, Stroud RM, Structure. 1998 Jul 15;6(7):839-48. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9687366 9687366]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Sage, C.R.]]
[[Category: Stout, T.J.]]
[[Category: Stroud, R.M.]]
[[Category: PO4]]
[[Category: substrate modules]]
[[Category: transferase (methyltransferase)]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:29:54 2007''