View source for 1jce

[[Image:1jce.gif|left|200px]]<br /><applet load="1jce" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1jce, resolution 2.1&Aring;" />
'''MREB FROM THERMOTOGA MARITIMA'''<br />

==Overview==
It was thought until recently that bacteria lack the actin or tubulin, filament networks that organize eukaryotic cytoplasm. However, we show, here that the bacterial MreB protein assembles into filaments with a, subunit repeat similar to that of F-actin-the physiological polymer of, eukaryotic actin. By elucidating the MreB crystal structure we demonstrate, that MreB and actin are very similar in three dimensions. Moreover, the, crystals contain protofilaments, allowing visualization of actin-like, strands at atomic resolution. The structure of the MreB protofilament is, in remarkably good agreement with the model for F-actin, showing that the, proteins assemble in identical orientations. The actin-like properties of, MreB explain the finding that MreB forms large fibrous spirals under the, cell membrane of rod-shaped cells, where they are involved in cell-shape, determination. Thus, prokaryotes are now known to possess homologues both, of tubulin, namely FtsZ, and of actin.

==About this Structure==
1JCE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JCE OCA]. 

==Reference==
Prokaryotic origin of the actin cytoskeleton., van den Ent F, Amos LA, Lowe J, Nature. 2001 Sep 6;413(6851):39-44. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11544518 11544518]
[[Category: Single protein]]
[[Category: Thermotoga maritima]]
[[Category: Amos, L.A.]]
[[Category: Ent, F.van.den.]]
[[Category: Lowe, J.]]
[[Category: actin]]
[[Category: ftsz]]
[[Category: hsp-70]]
[[Category: mbl]]
[[Category: mreb]]
[[Category: rod-shape determining]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:27:09 2007''