View source for 2ja3

[[Image:2ja3.gif|left|200px]]<br />
<applet load="2ja3" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2ja3, resolution 3.05&Aring;" />
'''CYTOPLASMIC DOMAIN OF THE HUMAN CHLORIDE TRANSPORTER CLC-5 IN COMPLEX WITH ADP'''<br />

==Overview==
The ubiquitous CBS domains, which are found as part of cytoplasmic domains, in the ClC family of chloride channels and transporters, have previously, been identified as building blocks for regulatory nucleotide-binding, sites. Here we report the structures of the cytoplasmic domain of the, human transporter ClC-5 in complex with ATP and ADP. The nucleotides bind, to a specific site in the protein. As determined by equilibrium dialysis, the affinities for ATP, ADP and AMP are in the high micromolar range., Point mutations that interfere with nucleotide binding change the, transport behavior of a ClC-5 mutant expressed in Xenopus laevis oocytes., Our results establish the structural and energetic basis for the, interaction of ClC-5 with nucleotides and provide a framework for future, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?17195847 (full description)]]

==About this Structure==
2JA3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ADP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JA3 OCA]]. 

==Reference==
Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5., Meyer S, Savaresi S, Forster IC, Dutzler R, Nat Struct Mol Biol. 2007 Jan;14(1):60-7. Epub 2006 Dec 31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17195847 17195847]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Dutzler, R.]]
[[Category: Forster, I.C.]]
[[Category: Meyer, S.]]
[[Category: Savaresi, S.]]
[[Category: ADP]]
[[Category: cbs domain]]
[[Category: chloride]]
[[Category: chloride channel]]
[[Category: chloride transporter]]
[[Category: clc]]
[[Category: disease mutation]]
[[Category: domain]]
[[Category: ion transport]]
[[Category: ionic channel]]
[[Category: membrane]]
[[Category: transmembrane]]
[[Category: transport]]
[[Category: transport protein]]
[[Category: voltage-gated channel]]

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