View source for 3lve

[[Image:3lve.gif|left|200px]]<br />
<applet load="3lve" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="3lve, resolution 2.0&Aring;" />
'''LEN Q38E MUTANT: A DOMAIN FLIP FROM A SINGLE AMINO ACID SUBSTITUTION'''<br />

==Overview==
BACKGROUND: The self-assembly properties of beta domains are important, features of diverse classes of proteins that include cell-adhesion, molecules, surface receptors and the immunoglobulin superfamily., Immunoglobulin light-chain variable domains are well suited to the study, of structural factors that determine dimerization, including how residues, at the interface influence the preferred dimer arrangement. RESULTS:, Single-site mutants of light-chain variable domain Len, designated LenQ38E, and LenK30T, formed 'flipped' dimers in which one domain was rotated by, about 180 degrees compared with the native protein. The dimer in the, native protein is similar to that found between variable domains in Fab, immunoglobulin fragments. When compared to the native dimer, more surface, area is ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9739086 (full description)]]

==About this Structure==
3LVE is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3LVE OCA]]. 

==Reference==
A domain flip as a result of a single amino-acid substitution., Pokkuluri PR, Huang DB, Raffen R, Cai X, Johnson G, Stevens PW, Stevens FJ, Schiffer M, Structure. 1998 Aug 15;6(8):1067-73. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9739086 9739086]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Pokkuluri, P.R.]]
[[Category: Schiffer, M.]]
[[Category: ZN]]
[[Category: immunoglobulin]]
[[Category: kappa-iv]]
[[Category: light chain dimer]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 22:11:31 2007''