View source for 2ca5

[[Image:2ca5.gif|left|200px]]<br />
<applet load="2ca5" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2ca5, resolution 2.1&Aring;" />
'''MXIH NEEDLE PROTEIN OF SHIGELLA FLEXNERI (MONOMERIC FORM, RESIDUES 1-78)'''<br />

==Overview==
Type III secretion systems are essential virulence determinants for many, Gram-negative bacterial pathogens. The type III secretion system consists, of cytoplasmic, transmembrane, and extracellular domains. The, extracellular domain is a hollow needle protruding above the bacterial, surface and is held within a basal body that traverses both bacterial, membranes. Effector proteins are translocated, via this external needle, directly into host cells, where they subvert normal cell functions to aid, infection. Physical contact with host cells initiates secretion and leads, to formation of a pore, thought to be contiguous with the needle channel, in the host-cell membrane. Here, we report the crystal structure of the, Shigella flexneri needle subunit MxiH and a complete model for the needle, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?16888041 (full description)]]

==About this Structure==
2CA5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]] with NA, IPA and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA]]. 

==Reference==
Molecular model of a type III secretion system needle: Implications for host-cell sensing., Deane JE, Roversi P, Cordes FS, Johnson S, Kenjale R, Daniell S, Booy F, Picking WD, Picking WL, Blocker AJ, Lea SM, Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12529-33. Epub 2006 Aug 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16888041 16888041]
[[Category: Shigella flexneri]]
[[Category: Single protein]]
[[Category: Blocker, A.J.]]
[[Category: Cordes, F.S.]]
[[Category: Deane, J.E.]]
[[Category: Johnson, S.]]
[[Category: Kenjale, R.]]
[[Category: Lea, S.M.]]
[[Category: Picking, W.D.]]
[[Category: Picking, W.L.]]
[[Category: Roversi, P.]]
[[Category: GOL]]
[[Category: IPA]]
[[Category: NA]]
[[Category: mxih]]
[[Category: needle complex]]
[[Category: protein transport]]
[[Category: type iii secretion system]]
[[Category: virulence]]

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