View source for 2ci8

[[Image:2ci8.gif|left|200px]]<br />
<applet load="2ci8" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2ci8, resolution 1.80&Aring;" />
'''SH2 DOMAIN OF HUMAN NCK1 ADAPTOR PROTEIN- UNCOMPLEXED'''<br />

==Overview==
Nck proteins are essential Src homology (SH) 2 and SH3 domain-bearing, adapters that modulate actin cytoskeleton dynamics by linking proline-rich, effector molecules to tyrosine kinases or phosphorylated signaling, intermediates. Two mammalian pathogens, enteropathogenic Escherichia coli, and vaccinia virus, exploit Nck as part of their infection strategy., Conflicting data indicate potential differences in the recognition, specificities of the SH2 domains of the isoproteins Nck1 (Nckalpha) and, Nck2 (Nckbeta and Grb4). We have characterized the binding specificities, of both SH2 domains and find them to be essentially indistinguishable., Crystal structures of both domains in complex with phosphopeptides derived, from the enteropathogenic E. coli protein Tir concur in identifying highly, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?16636066 (full description)]]

==About this Structure==
2CI8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4 and 1PE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CI8 OCA]]. 

==Reference==
The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains., Frese S, Schubert WD, Findeis AC, Marquardt T, Roske YS, Stradal TE, Heinz DW, J Biol Chem. 2006 Jun 30;281(26):18236-45. Epub 2006 Apr 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16636066 16636066]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Findeis, A.C.]]
[[Category: Frese, S.]]
[[Category: Heinz, D.W.]]
[[Category: Marquardt, T.]]
[[Category: Roske, Y.S.]]
[[Category: Schubert, W.D.]]
[[Category: Stradal, T.E.B.]]
[[Category: 1PE]]
[[Category: SO4]]
[[Category: binding specificity]]
[[Category: host-pathogen]]
[[Category: interactions]]
[[Category: phosphorylation]]
[[Category: sh2-domain]]
[[Category: sh3 domain]]

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