View source for 1ygo

[[Image:1ygo.gif|left|200px]]<br /><applet load="1ygo" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1ygo" />
'''Solution Structure of the pelle Death Domain'''<br />

==Overview==
The interaction between the death domains (DDs) of Tube and the protein, kinase Pelle is an important component of the Toll pathway. Published, crystallographic data suggests that the Pelle-Tube DD interface is plastic, and implies that in addition to the two predominant Pelle-Tube interfaces, a third interaction is possible. We present the NMR solution structure of, the isolated death domain of Pelle and a study of the interaction between, the DDs of Pelle and Tube. Our data suggests the solution structure of the, isolated Pelle DD is similar to that of Pelle DD in complex with Tube., Additionally, they suggest that the plasticity observed in the crystal, structure may not be relevant in the functioning death domain complex.

==About this Structure==
1YGO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YGO OCA]. 

==Reference==
Solution structure of the isolated Pelle death domain., Moncrieffe MC, Stott KM, Gay NJ, FEBS Lett. 2005 Jul 18;579(18):3920-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16004997 16004997]
[[Category: Drosophila melanogaster]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Single protein]]
[[Category: Gay, N.J.]]
[[Category: Moncrieffe, M.C.]]
[[Category: Stott, K.M.]]
[[Category: anti-parallel 6 helix bundle]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:45:42 2007''