View source for 2zm4

{{Seed}}
[[Image:2zm4.png|left|200px]]

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{{STRUCTURE_2zm4|  PDB=2zm4  |  SCENE=  }} 

===Crystal structure of imidazo quinoxaline 1 bound to the kinase domain of human LCK, activated form (auto-phosphorylated on TYR394)===


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{{ABSTRACT_PUBMED_18977146}}

==Disease==
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]

==About this Structure==
2ZM4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZM4 OCA]. 

==Reference==
The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase., Ozawa T, Tsuji E, Ozawa M, Handa C, Mukaiyama H, Nishimura T, Kobayashi S, Okazaki K, Bioorg Med Chem. 2008 Dec 15;16(24):10311-8. Epub 2008 Oct 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18977146 18977146]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Single protein]]
[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Chromosomal rearrangement]]
[[Category: Cytoplasm]]
[[Category: Disease mutation]]
[[Category: Host-virus interaction]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Myristate]]
[[Category: Nucleotide-binding]]
[[Category: Palmitate]]
[[Category: Phosphoprotein]]
[[Category: Phosphorylation]]
[[Category: Proto-oncogene]]
[[Category: Sh2 domain]]
[[Category: Sh3 domain]]
[[Category: Signal transduction]]
[[Category: Transferase]]
[[Category: Tyrosine-protein kinase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb  4 20:05:25 2009''