View source for 3bys

{{Seed}}
[[Image:3bys.png|left|200px]]

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{{STRUCTURE_3bys|  PDB=3bys  |  SCENE=  }} 

===co-crystal structure of Lck and aminopyrimidine amide 10b===


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{{ABSTRACT_PUBMED_18321037}}

==Disease==
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]

==About this Structure==
3BYS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYS OCA]. 

==Reference==
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation., DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Chai L, Chaffee SC, Deak HL, Epstein LF, Faust T, Gallant P, Gore A, Gu Y, Henkle B, Hsieh F, Huang X, Kim JL, Lee JH, Martin MW, McGowan DC, Metz D, Mohn D, Morgenstern KA, Oliveira-dos-Santos A, Patel VF, Powers D, Rose PE, Schneider S, Tomlinson SA, Tudor YY, Turci SM, Welcher AA, Zhao H, Zhu L, Zhu X, J Med Chem. 2008 Mar 27;51(6):1681-94. Epub 2008 Mar 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18321037 18321037]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Huang, X.]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Chromosomal rearrangement]]
[[Category: Cytoplasm]]
[[Category: Disease mutation]]
[[Category: Host-virus interaction]]
[[Category: Kinase domain]]
[[Category: Lck]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Myristate]]
[[Category: Nucleotide-binding]]
[[Category: Palmitate]]
[[Category: Phosphoprotein]]
[[Category: Proto-oncogene]]
[[Category: Sh2 domain]]
[[Category: Sh3 domain]]
[[Category: Transferase]]
[[Category: Tyrosine-protein kinase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 09:14:01 2008''