View source for 1scm

[[Image:1scm.gif|left|200px]]<br /><applet load="1scm" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1scm, resolution 2.8&Aring;" />
'''STRUCTURE OF THE REGULATORY DOMAIN OF SCALLOP MYOSIN AT 2.8 ANGSTROMS RESOLUTION'''<br />

==Overview==
The regulatory domain of scallop myosin is a three-chain protein complex, that switches on this motor in response to Ca2+ binding. This domain has, been crystallized and the structure solved to 2.8 A resolution. Side-chain, interactions link the two light chains in tandem to adjacent segments of, the heavy chain bearing the IQ-sequence motif. The Ca(2+)-binding site is, a novel EF-hand motif on the essential light chain and is stabilized by, linkages involving the heavy chain and both light chains, accounting for, the requirement of all three chains for Ca2+ binding and regulation in the, intact myosin molecule.

==About this Structure==
1SCM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SCM OCA]. 

==Reference==
Structure of the regulatory domain of scallop myosin at 2.8 A resolution., Xie X, Harrison DH, Schlichting I, Sweet RM, Kalabokis VN, Szent-Gyorgyi AG, Cohen C, Nature. 1994 Mar 24;368(6469):306-12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8127365 8127365]
[[Category: Argopecten irradians]]
[[Category: Protein complex]]
[[Category: Cohen, C.]]
[[Category: Xie, X.]]
[[Category: CA]]
[[Category: calcium-binding protein]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:16:35 2007''