View source for 3dox

{{Seed}}
[[Image:3dox.jpg|left|200px]]

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{{STRUCTURE_3dox|  PDB=3dox  |  SCENE=  }} 

===X-ray structure of HIV-1 protease in situ product complex===


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==About this Structure==
3DOX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_hxb2_group_m_subtype_b) Human immunodeficiency virus type 1 (isolate hxb2 group m subtype b)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DOX OCA]. 

==Reference==
X-ray structure of HIV-1 protease in situ product complex., Bihani S, Das A, Prashar V, Ferrer JL, Hosur MV, Proteins. 2008 Aug 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18704947 18704947]

1.9 A x-ray study shows closed flap conformation in crystals of tethered HIV-1 PR., Pillai B, Kannan KK, Hosur MV, Proteins. 2001 Apr 1;43(1):57-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11170214 11170214]

Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex., Kumar M, Prashar V, Mahale S, Hosur MV, Biochem J. 2005 Jul 15;389(Pt 2):365-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15794743 15794743]

Rapid screening for HIV-1 protease inhibitor leads through X-ray diffraction., Pillai B, Kannan KK, Bhat SV, Hosur MV, Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):594-6. Epub 2004, Feb 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14993705 14993705]

Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates., Das A, Prashar V, Mahale S, Serre L, Ferrer JL, Hosur MV, Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18464-9. Epub 2006 Nov 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17116869 17116869]
[[Category: HIV-1 retropepsin]]
[[Category: Protein complex]]
[[Category: Bihani, S.]]
[[Category: Das, A.]]
[[Category: Ferrer, J L.]]
[[Category: Hosur, M V.]]
[[Category: Prashar, V.]]
[[Category: Aid]]
[[Category: Aspartyl protease]]
[[Category: Capsid maturation]]
[[Category: Capsid protein]]
[[Category: Catalysis]]
[[Category: Cytoplasm]]
[[Category: Dna integration]]
[[Category: Dna recombination]]
[[Category: Dna-directed dna polymerase]]
[[Category: Endonuclease]]
[[Category: Hiv-1 protease]]
[[Category: Host-virus interaction]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]
[[Category: Lipoprotein]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Multifunctional enzyme]]
[[Category: Myristate]]
[[Category: Nuclease]]
[[Category: Nucleotidyltransferase]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Protease]]
[[Category: Reaction intermediate]]
[[Category: Ribosomal frameshifting]]
[[Category: Rna-binding]]
[[Category: Rna-directed dna polymerase]]
[[Category: Transferase]]
[[Category: Transition state]]
[[Category: Viral nucleoprotein]]
[[Category: Virion]]
[[Category: X-ray crystallography]]
[[Category: Zinc]]
[[Category: Zinc-finger]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 10 10:33:05 2008''