View source for 3d4n

{{Seed}}
[[Image:3d4n.png|left|200px]]

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{{STRUCTURE_3d4n|  PDB=3d4n  |  SCENE=  }} 

===Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Sulfonamide Inhibitor===


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{{ABSTRACT_PUBMED_18553955}}

==About this Structure==
3D4N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D4N OCA]. 

==Reference==
Discovery of Novel, Potent Benzamide Inhibitors of 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model., Julian LD, Wang Z, Bostick T, Caille S, Choi R, Degraffenreid M, Di Y, He X, Hungate RW, Jaen JC, Liu J, Monshouwer M, McMinn D, Rew Y, Sudom A, Sun D, Tu H, Ursu S, Walker N, Yan X, Ye Q, Powers JP, J Med Chem. 2008 Jun 14;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18553955 18553955]
[[Category: 11-beta-hydroxysteroid dehydrogenase]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Liu, J.]]
[[Category: Sudom, A.]]
[[Category: Walker, N P.]]
[[Category: Wang, Z.]]
[[Category: 11beta]]
[[Category: Dehydrogenase]]
[[Category: Endoplasmic reticulum]]
[[Category: Glycoprotein]]
[[Category: Hydroxysteroid]]
[[Category: Lipid metabolism]]
[[Category: Membrane]]
[[Category: Microsome]]
[[Category: Nadp]]
[[Category: Oxidoreductase]]
[[Category: Polymorphism]]
[[Category: Signal-anchor]]
[[Category: Steroid metabolism]]
[[Category: Transmembrane]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:18:36 2008''