View source for 1pho

[[Image:1pho.gif|left|200px]]<br /><applet load="1pho" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1pho, resolution 3.0&Aring;" />
'''CRYSTAL STRUCTURES EXPLAIN FUNCTIONAL PROPERTIES OF TWO E. COLI PORINS'''<br />

==Overview==
Porins form aqueous channels that aid the diffusion of small hydrophilic, molecules across the outer membrane of Gram-negative bacteria. The crystal, structures of matrix porin and phosphoporin both reveal trimers of, identical subunits, each subunit consisting of a 16-stranded anti-parallel, beta-barrel containing a pore. A long loop inside the barrel contributes, to a constriction of the channel where the charge distribution affects ion, selectivity. The structures explain at the molecular level functional, characteristics and their alterations by known mutations.

==About this Structure==
1PHO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PHO OCA]. 

==Reference==
Crystal structures explain functional properties of two E. coli porins., Cowan SW, Schirmer T, Rummel G, Steiert M, Ghosh R, Pauptit RA, Jansonius JN, Rosenbusch JP, Nature. 1992 Aug 27;358(6389):727-33. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1380671 1380671]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Cowan, S.W.]]
[[Category: Jansonius, J.N.]]
[[Category: Schirmer, T.]]
[[Category: outer membrane protein]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 23:49:27 2007''