View source for 2gfs

{{Seed}}
[[Image:2gfs.png|left|200px]]

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===P38 Kinase Crystal Structure in complex with RO3201195===


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==About this Structure==
2GFS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GFS OCA]. 

==Reference==
Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)ph enyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase., Goldstein DM, Alfredson T, Bertrand J, Browner MF, Clifford K, Dalrymple SA, Dunn J, Freire-Moar J, Harris S, Labadie SS, La Fargue J, Lapierre JM, Larrabee S, Li F, Papp E, McWeeney D, Ramesha C, Roberts R, Rotstein D, San Pablo B, Sjogren EB, So OY, Talamas FX, Tao W, Trejo A, Villasenor A, Welch M, Welch T, Weller P, Whiteley PE, Young K, Zipfel S, J Med Chem. 2006 Mar 9;49(5):1562-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16509574 16509574]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Single protein]]
[[Category: Bertrand, J.]]
[[Category: Harris, S F.]]
[[Category: Villasenor, A.]]
[[Category: Map kinase]]
[[Category: P38]]
[[Category: Serine/threonine kinase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:09:52 2008''