View source for 1v0j

[[Image:1v0j.gif|left|200px]]<br />
<applet load="1v0j" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1v0j, resolution 2.25&Aring;" />
'''UDP-GALACTOPYRANOSE MUTASE FROM MYCOBACTERIUM TUBERCULOSIS'''<br />

==Overview==
Uridine diphosphogalactofuranose (UDP-Galf) is the precursor of the, d-galactofuranose sugar found in bacterial and parasitic cell walls, including those of many pathogens. UDP-Galf is made from, UDP-galactopyranose by the enzyme UDP-galactopyranose mutase. The enzyme, requires the reduced FADH- co-factor for activity. The structure of the, Mycobacterium tuberculosis mutase with FAD has been determined to 2.25 A., The structures of Klebsiella pneumoniae mutase with FAD and with FADH-, bound have been determined to 2.2 A and 2.35 A resolution, respectively., This is the first report of the FADH(-)-containing structure. Two, flavin-dependent mechanisms for the enzyme have been proposed, one, which, involves a covalent adduct being formed at the flavin and the other based, on electron ... [[http://ispc.weizmann.ac.il/pmbin/getpm?15843027 (full description)]]

==About this Structure==
1V0J is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with FAD and BCN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1V0J OCA]]. 

==Reference==
Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state., Beis K, Srikannathasan V, Liu H, Fullerton SW, Bamford VA, Sanders DA, Whitfield C, McNeil MR, Naismith JH, J Mol Biol. 2005 May 13;348(4):971-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15843027 15843027]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: Beis, K.]]
[[Category: Naismith, J.H.]]
[[Category: BCN]]
[[Category: FAD]]
[[Category: flavoprotein]]
[[Category: isomerase]]
[[Category: mutase]]

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