View source for 1oog

[[Image:1oog.jpg|left|200px]]<br /><applet load="1oog" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1oog, resolution 1.45&Aring;" />
'''Complex of Drosophila odorant binding protein LUSH with propanol'''<br />

==Overview==
We have solved the high-resolution crystal structures of the Drosophila, melanogaster alcohol-binding protein LUSH in complex with a series of, short-chain n-alcohols. LUSH is the first known nonenzyme protein with a, defined in vivo alcohol-binding function. The structure of LUSH reveals a, set of molecular interactions that define a specific alcohol-binding site., A group of amino acids, Thr57, Ser52 and Thr48, form a network of, concerted hydrogen bonds between the protein and the alcohol that provides, a structural motif to increase alcohol-binding affinity at this site. This, motif seems to be conserved in a number of mammalian ligand-gated ion, channels that are directly implicated in the pharmacological effects of, alcohol. Further, these sequences are found in regions of ion channels, that are known to confer alcohol sensitivity. We suggest that the, alcohol-binding site in LUSH represents a general model for, alcohol-binding sites in proteins.

==About this Structure==
1OOG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with ACT and POL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OOG OCA]. 

==Reference==
Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster., Kruse SW, Zhao R, Smith DP, Jones DN, Nat Struct Biol. 2003 Sep;10(9):694-700. Epub 2003 Jul 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12881720 12881720]
[[Category: Drosophila melanogaster]]
[[Category: Single protein]]
[[Category: Jones, D.N.M.]]
[[Category: Kruse, S.W.]]
[[Category: Smith, D.P.]]
[[Category: Zhao, R.]]
[[Category: ACT]]
[[Category: POL]]
[[Category: alcohol]]
[[Category: lush]]
[[Category: odorant binding]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 23:03:56 2007''