View source for 1lz8

[[Image:1lz8.jpg|left|200px]]<br /><applet load="1lz8" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1lz8, resolution 1.53&Aring;" />
'''LYSOZYME PHASED ON ANOMALOUS SIGNAL OF SULFURS AND CHLORINES'''<br />

==Overview==
A general method for solving the phase problem from native crystals of, macromolecules has long eluded structural biology. For well diffracting, crystals this goal can now be achieved, as is shown here, thanks to modern, data collection techniques and new statistical phasing algorithms. Using, solely a native crystal of tetragonal hen egg-white lysozyme, a protein of, 14 kDa molecular mass, it was possible to detect the positions of the ten, sulfur and seven chlorine atoms from their anomalous signal, and proceed, from there to obtain an electron-density map of very high quality.

==About this Structure==
1LZ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with CL and NA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LZ8 OCA]. 

==Reference==
Can anomalous signal of sulfur become a tool for solving protein crystal structures?, Dauter Z, Dauter M, de La Fortelle E, Bricogne G, Sheldrick GM, J Mol Biol. 1999 May 28;289(1):83-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10339407 10339407]
[[Category: Gallus gallus]]
[[Category: Lysozyme]]
[[Category: Single protein]]
[[Category: Bricogne, G.]]
[[Category: Dauter, M.]]
[[Category: Dauter, Z.]]
[[Category: Fortelle, E.De.La.]]
[[Category: Sheldrick, G.M.]]
[[Category: CL]]
[[Category: NA]]
[[Category: glycosidase]]
[[Category: hydrolase]]
[[Category: o-glycosyl]]

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