View source for 2nnx

{{Seed}}
[[Image:2nnx.png|left|200px]]

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{{STRUCTURE_2nnx|  PDB=2nnx  |  SCENE=  }} 

===Crystal Structure of the H46R, H48Q double mutant of human [Cu-Zn] Superoxide Dismutase===


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{{ABSTRACT_PUBMED_17092942}}

==Disease==
Known disease associated with this structure: Amyotrophic lateral sclerosis, due to SOD1 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147450 147450]]

==About this Structure==
2NNX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNX OCA]. 

==Reference==
Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability., Wang J, Caruano-Yzermans A, Rodriguez A, Scheurmann JP, Slunt HH, Cao X, Gitlin J, Hart PJ, Borchelt DR, J Biol Chem. 2007 Jan 5;282(1):345-52. Epub 2006 Nov 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17092942 17092942]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Superoxide dismutase]]
[[Category: Hart, P J.]]
[[Category: Schuermann, J P.]]
[[Category: Cu-zn superoxide dismutase]]
[[Category: Familial amyotrophic lateral sclerosis mutant]]
[[Category: Human]]
[[Category: Oxidoreductase]]
[[Category: Superoxide acceptor]]

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