View source for 1uns

[[Image:1uns.gif|left|200px]]<br />
<applet load="1uns" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1uns, resolution 2.0&Aring;" />
'''IDENTIFICATION OF A SECONDARY ZINC-BINDING SITE IN STAPHYLOCOCCAL ENTEROTOXIN C2: IMPLICATIONS FOR SUPERANTIGEN RECOGNITION'''<br />

==Overview==
The previously determined crystal structure of the superantigen, staphylococcal enterotoxin C2 (SEC2) showed binding of a single zinc ion, located between the N- and C-terminal domains. Here we present the crystal, structure of SEC2 determined to 2.0 A resolution in the presence of, additional zinc. The structure revealed the presence of a secondary, zinc-binding site close to the major histocompatibility complex, (MHC)-binding site of the toxin and some 28 A away from the primary, zinc-binding site of the toxin found in previous studies. T cell, stimulation assays showed that varying the concentration of zinc ions, present affected the activity of the toxin and we observed that high zinc, concentrations considerably inhibited T cell responses. This indicates, that SEC2 may have multiple ... [[http://ispc.weizmann.ac.il/pmbin/getpm?14559915 (full description)]]

==About this Structure==
1UNS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UNS OCA]]. 

==Reference==
Identification of a secondary zinc-binding site in staphylococcal enterotoxin C2. Implications for superantigen recognition., Papageorgiou AC, Baker MD, McLeod JD, Goda SK, Manzotti CN, Sansom DM, Tranter HS, Acharya KR, J Biol Chem. 2004 Jan 9;279(2):1297-303. Epub 2003 Oct 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14559915 14559915]
[[Category: Single protein]]
[[Category: Staphylococcus aureus]]
[[Category: Acharya, K.R.]]
[[Category: Baker, M.D.]]
[[Category: Goda, S.]]
[[Category: Mcleod, J.D.]]
[[Category: Papageorgiou, A.C.]]
[[Category: Sansom, D.M.]]
[[Category: Tranter, H.S.]]
[[Category: ZN]]
[[Category: enterotoxin]]
[[Category: superantigen]]
[[Category: toxin]]
[[Category: zinc-binding site]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:11:25 2007''