View source for 1jqq

[[Image:1jqq.jpg|left|200px]]<br /><applet load="1jqq" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1jqq, resolution 2.65&Aring;" />
'''Crystal structure of Pex13p(301-386) SH3 domain'''<br />

==Overview==
While the function of most small signaling domains is confined to binary, ligand interactions, the peroxisomal Pex13p SH3 domain has the unique, capacity of binding to two different ligands, Pex5p and Pex14p. We have, used this domain as a model to decipher its structurally independent, ligand binding sites. By the combined use of X-ray crystallography, NMR, spectroscopy, and circular dichroism, we show that the two ligands bind in, unrelated conformations to patches located at opposite surfaces of this, SH3 domain. Mutations in the Pex13p SH3 domain that abolish interactions, within the Pex13p-Pex5p interface specifically impair PTS1-dependent, protein import into yeast peroxisomes.

==About this Structure==
1JQQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JQQ OCA]. 

==Reference==
Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain., Douangamath A, Filipp FV, Klein AT, Barnett P, Zou P, Voorn-Brouwer T, Vega MC, Mayans OM, Sattler M, Distel B, Wilmanns M, Mol Cell. 2002 Nov;10(5):1007-17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12453410 12453410]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Barnett, P.]]
[[Category: Distel, B.]]
[[Category: Douangamath, A.]]
[[Category: Mayans, O.]]
[[Category: Wilmanns, M.]]
[[Category: compact beta-barrel of five anti-parrallel beta-strands]]

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