View source for 1gnd

[[Image:1gnd.gif|left|200px]]<br /><applet load="1gnd" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1gnd, resolution 1.81&Aring;" />
'''GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM'''<br />

==Overview==
The crystal structure of the bovine alpha-isoform of Rab GDP-dissociation, inhibitor (GDI), which functions in vesicle-membrane transport to recycle, and regulate Rab GTPases, has been determined to a resolution of 1.81 A., GDI is constructed of two main structural units, a large complex, multisheet domain I and a smaller alpha-helical domain II. The structural, organization of domain I is surprisingly closely related to FAD-containing, monooxygenases and oxidases. Sequence-conserved regions common to GDI and, the choroideraemia gene product, which delivers Rab to catalytic subunits, of Rab geranylgeranyltransferase II, are clustered on one face of the, molecule. The two most sequence-conserved regions, which form a compact, structure at the apex of GDI, are shown by site-directed mutagenesis to, play a critical role in the binding of Rab proteins.

==About this Structure==
1GND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GND OCA]. 

==Reference==
Structure and mutational analysis of Rab GDP-dissociation inhibitor., Schalk I, Zeng K, Wu SK, Stura EA, Matteson J, Huang M, Tandon A, Wilson IA, Balch WE, Nature. 1996 May 2;381(6577):42-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8609986 8609986]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Balch, W.E.]]
[[Category: Huang, M.]]
[[Category: Metteson, J.]]
[[Category: Schalk, I.]]
[[Category: Stura, E.A.]]
[[Category: Tandon, A.]]
[[Category: Wilson, I.A.]]
[[Category: Wu, S.K.]]
[[Category: Zeng, K.]]
[[Category: gtpase activation]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:11:03 2007''