View source for 1dsl

[[Image:1dsl.gif|left|200px]]<br /><applet load="1dsl" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1dsl, resolution 1.55&Aring;" />
'''GAMMA B CRYSTALLIN C-TERMINAL DOMAIN'''<br />

==Overview==
We use protein engineering and crystallography to simulate aspects of the, early evolution of beta gamma-crystallins by observing how a single domain, oligomerizes in response to changes in a sequence extension. The crystal, structure of the C-terminal domain of gamma beta-crystallin with its, four-residue C-terminal extension shows that the domain does not form a, symmetric homodimer analogous to the two-domain pairing in beta, gamma-crystallins. Instead the C-terminal extension now forms heterologous, interactions with other domains leading to the solvent exposure of the, natural hydrophobic interface with a consequent loss in protein, solubility. However, this domain truncated by just the C-terminal tyrosine, forms a symmetric homodimer of domains in the crystal lattice.

==About this Structure==
1DSL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DSL OCA]. 

==Reference==
The X-ray structures of two mutant crystallin domains shed light on the evolution of multi-domain proteins., Norledge BV, Mayr EM, Glockshuber R, Bateman OA, Slingsby C, Jaenicke R, Driessen HP, Nat Struct Biol. 1996 Mar;3(3):267-74. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8605629 8605629]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Bateman, O.A.]]
[[Category: Driessen, H.P.C.]]
[[Category: Glockshuber, R.]]
[[Category: Jaenicke, R.]]
[[Category: Mayr, E.M.]]
[[Category: Norledge, B.V.]]
[[Category: Slingsby, C.]]
[[Category: eye lens protein]]
[[Category: multigene family]]

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