View source for 1dfj

[[Image:1dfj.jpg|left|200px]]<br /><applet load="1dfj" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1dfj, resolution 2.5&Aring;" />
'''RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A'''<br />

==Overview==
The leucine-rich repeat is a recently characterized structural motif used, in molecular recognition processes as diverse as signal transduction, cell, adhesion, cell development, DNA repair and RNA processing. We present here, the crystal structure at 2.5 A resolution of the complex between, ribonuclease A and ribonuclease inhibitor, a protein built entirely of, leucine-rich repeats. The unusual non-globular structure of ribonuclease, inhibitor, its solvent-exposed parallel beta-sheet and the conformational, flexibility of the structure are used in the interaction; they appear to, be the principal reasons for the effectiveness of leucine-rich repeats as, protein-binding motifs. The structure can serve as a model for the, interactions of other proteins containing leucine-rich repeats with their, ligands.

==About this Structure==
1DFJ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with SO4 and ACE as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DFJ OCA]. 

==Reference==
A structural basis of the interactions between leucine-rich repeats and protein ligands., Kobe B, Deisenhofer J, Nature. 1995 Mar 9;374(6518):183-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7877692 7877692]
[[Category: Bos taurus]]
[[Category: Pancreatic ribonuclease]]
[[Category: Protein complex]]
[[Category: Sus scrofa]]
[[Category: Deisenhofer, J.]]
[[Category: Kobe, B.]]
[[Category: ACE]]
[[Category: SO4]]
[[Category: complex (ribonuclease/inhibitor)]]
[[Category: hydrolase]]
[[Category: leucine-rich repeats]]
[[Category: ribonuclease]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:14:44 2007''