View source for 1ass

[[Image:1ass.gif|left|200px]]<br /><applet load="1ass" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1ass, resolution 2.3&Aring;" />
'''APICAL DOMAIN OF THE CHAPERONIN FROM THERMOPLASMA ACIDOPHILUM'''<br />

==Overview==
The crystal structure of the substrate binding domain of the thermosome, the archaeal group II chaperonin, has been determined at 2.3 A resolution., The core resembles the apical domain of GroEL but lacks the hydrophobic, residues implied in binding of substrates to group I chaperonins. Rather, a large hydrophobic surface patch is found in a novel helix-turn-helix, motif, which is characteristic of all group II chaperonins including the, eukaryotic TRiC/CCT complex. Models of the holochaperonin, which are, consistent with cryo electron microscopy data, suggest a dual role of this, helical protrusion in substrate binding and controlling access to the, central cavity independent of a GroES-like cochaperonin.

==About this Structure==
1ASS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum] with NA and PO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ASS OCA]. 

==Reference==
Structure of the substrate binding domain of the thermosome, an archaeal group II chaperonin., Klumpp M, Baumeister W, Essen LO, Cell. 1997 Oct 17;91(2):263-70. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9346243 9346243]
[[Category: Single protein]]
[[Category: Thermoplasma acidophilum]]
[[Category: Baumeister, W.]]
[[Category: Essen, L.O.]]
[[Category: Klumpp, M.]]
[[Category: NA]]
[[Category: PO4]]
[[Category: atp-binding]]
[[Category: chaperonin]]
[[Category: groel]]
[[Category: hsp60]]
[[Category: tcp1]]
[[Category: thermoplasma acidophilum]]
[[Category: thermosome]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:06:39 2007''