View source for 1aft

[[Image:1aft.gif|left|200px]]<br /><applet load="1aft" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1aft" />
'''SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES'''<br />

==Overview==
The structure of peptide N-AcYTLDADF when bound to the large subunit of, mouse ribonucleotide reductase has been elucidated by transfer NOE. This, structure suggests a general design for type 1 RR inhibitors.

==About this Structure==
1AFT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with ACE as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AFT OCA]. 

==Reference==
NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit., Fisher A, Laub PB, Cooperman BS, Nat Struct Biol. 1995 Nov;2(11):951-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7583667 7583667]
[[Category: Ribonucleoside-diphosphate reductase]]
[[Category: Single protein]]
[[Category: Barwis, B.A.]]
[[Category: Cooperman, B.S.]]
[[Category: Fisher, A.L.]]
[[Category: Furst, G.T.]]
[[Category: Hamann, C.S.]]
[[Category: Laub, P.B.]]
[[Category: ACE]]
[[Category: nonstandard type i turn]]
[[Category: peptide inhibitors]]
[[Category: restrained molecular dynamics]]
[[Category: ribonucleotide reductase]]
[[Category: transferred noesy]]

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