View source for 2viu

[[Image:2viu.gif|left|200px]]

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{{STRUCTURE_2viu|  PDB=2viu  |  SCENE=  }} 

'''INFLUENZA VIRUS HEMAGGLUTININ'''


==Overview==
The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies.

==About this Structure==
2VIU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIU OCA]. 

==Reference==
Antigen distortion allows influenza virus to escape neutralization., Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T, Nat Struct Biol. 1998 Feb;5(2):119-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9461077 9461077]
[[Category: Single protein]]
[[Category: Unidentified influenza virus]]
[[Category: Bizebard, T.]]
[[Category: Fleury, D.]]
[[Category: Gigant, B.]]
[[Category: Knossow, M.]]
[[Category: Skehel, J J.]]
[[Category: Wharton, S A.]]
[[Category: Envelope protein]]
[[Category: Glycoprotein]]
[[Category: Hemagglutinin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:53:48 2008''