View source for 2qrn

[[Image:2qrn.jpg|left|200px]]

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{{STRUCTURE_2qrn|  PDB=2qrn  |  SCENE=  }} 

'''Human Deoxycytidine kinase dCMP, UDP, Mg ion product complex'''


==Overview==
Human deoxycytidine kinase (dCK) is involved in the nucleotide-biosynthesis salvage pathway and has also been shown to phosphorylate several antitumor and antiviral prodrugs. The structures of dCK alone and the dead-end complex of dCK with substrate nucleoside and product ADP or UDP have previously been reported; however, there is currently no structure available for a substrate or product complex. Here, the structures of dCK complexes with the products dCMP, UDP and Mg2+ ion, and with dAMP, UDP and Mg2+ ion are reported. Structural comparisons show that the product complexes with UDP and a dead-end complex with substrate and UDP have similar active-site conformations.

==About this Structure==
2QRN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QRN OCA]. 

==Reference==
Structures of human deoxycytidine kinase product complexes., Soriano EV, Clark VC, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1201-7. Epub 2007, Nov 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18084067 18084067]
[[Category: Deoxycytidine kinase]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Ealick, S E.]]
[[Category: Soriano, E V.]]
[[Category: Atp-binding]]
[[Category: Deoxycytidine kinase]]
[[Category: Deoxycytidine monophosphate]]
[[Category: Nucleotide-binding]]
[[Category: Nucleus]]
[[Category: Phosphorylation]]
[[Category: Transferase]]
[[Category: Uridine diphosphate]]
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