View source for 2pbh

[[Image:2pbh.gif|left|200px]]

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{{STRUCTURE_2pbh|  PDB=2pbh  |  SCENE=  }} 

'''CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 3.3 ANGSTROM RESOLUTION'''


==Overview==
A wild-type human procathepsin B was expressed, crystallized in two crystal forms and its crystal structure determined at 3.2 and 3.3 Angstroms resolution. The structure reveals that the propeptide folds on the cathepsin B surface, shielding the enzyme active site from exposure to solvent. The structure of the enzymatically active domains is virtually identical to that of the native enzyme [Musil et al. (1991) EMBO J. 10, 2321-2330]: the main difference is that the occluding loop residues are lifted above the body of the mature enzyme, supporting the propeptide structure.

==About this Structure==
2PBH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PBH OCA]. 

==Reference==
Crystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide., Turk D, Podobnik M, Kuhelj R, Dolinar M, Turk V, FEBS Lett. 1996 Apr 22;384(3):211-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8617355 8617355]
[[Category: Cathepsin B]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Kuhelj, R.]]
[[Category: Podobnik, M.]]
[[Category: Turk, D.]]
[[Category: Turk, V.]]
[[Category: Cathepsin b]]
[[Category: Crystal structure]]
[[Category: Cysteine protease]]
[[Category: Papain]]
[[Category: Proenzyme]]
[[Category: Thiol protease]]
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