View source for 1htm

[[Image:1htm.gif|left|200px]]<br />
<applet load="1htm" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1htm, resolution 2.5&Aring;" />
'''STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION'''<br />

==Overview==
Low pH induces a conformational change in the influenza virus, haemagglutinin, which then mediates fusion of the viral and host cell, membranes. The three-dimensional structure of a fragment of the, haemagglutinin in this conformation reveals a major refolding of the, secondary and tertiary structure of the molecule. The apolar fusion, peptide moves at least 100 A to one tip of the molecule. At the other end, a helical segment unfolds, a subdomain relocates reversing the chain, direction, and part of the structure becomes disordered.

==About this Structure==
1HTM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Uncultured_beta_proteobacterium_umtra-608 Uncultured beta proteobacterium umtra-608]. The following page contains interesting information on the relation of 1HTM with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb76_1.html Hemagglutinin]]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. 

==Reference==
Structure of influenza haemagglutinin at the pH of membrane fusion., Bullough PA, Hughson FM, Skehel JJ, Wiley DC, Nature. 1994 Sep 1;371(6492):37-43. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8072525 8072525]
[[Category: Hemagglutinin]]
[[Category: Protein complex]]
[[Category: Uncultured beta proteobacterium umtra-608]]
[[Category: Bullough, P.A.]]
[[Category: Hughson, F.M.]]
[[Category: Skehel, J.J.]]
[[Category: Wiley, D.C.]]
[[Category: influenza virus hemagglutinin]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:01:31 2007''