View source for 2ren

[[Image:2ren.gif|left|200px]]<br />
<applet load="2ren" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2ren, resolution 2.5&Aring;" />
'''STRUCTURE OF RECOMBINANT HUMAN RENIN, A TARGET FOR CARDIOVASCULAR-ACTIVE DRUGS, AT 2.5 ANGSTROMS RESOLUTION'''<br />

==Overview==
The x-ray crystal structure of recombinant human renin has been, determined. Molecular dynamics techniques that included crystallographic, data as a restraint were used to improve an initial model based on porcine, pepsinogen. The present agreement factor for data from 8.0 to 2.5, angstroms (A) is 0.236. Some of the surface loops are poorly determined, and these disordered regions border a 30 A wide solvent channel., Comparison of renin with other aspartyl proteinases shows that, although, the structural cores and active sites are highly conserved, surface, residues, some of which are critical for specificity, vary greatly (up to, 10A). Knowledge of the actual structure, as opposed to the use of models, based on related enzymes, should facilitate the design of renin, inhibitors.

==Disease==
Known diseases associated with this structure: Hyperproreninemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=179820 179820]], Renal tubular dysgenesis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=179820 179820]]

==About this Structure==
2REN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2REN OCA]. 

==Reference==
Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution., Sielecki AR, Hayakawa K, Fujinaga M, Murphy ME, Fraser M, Muir AK, Carilli CT, Lewicki JA, Baxter JD, James MN, Science. 1989 Mar 10;243(4896):1346-51. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2493678 2493678]
[[Category: Homo sapiens]]
[[Category: Renin]]
[[Category: Single protein]]
[[Category: James, M.N.G.]]
[[Category: Sielecki, A.R.]]
[[Category: NAG]]
[[Category: hydrolase(acid proteinase)]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:36:59 2007''