View source for 2hdf

[[Image:2hdf.jpg|left|200px]]

<!--
The line below this paragraph, containing "STRUCTURE_2hdf", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet) 
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_2hdf|  PDB=2hdf  |  SCENE=  }} 

'''Crystal structure of the Colicin I receptor Cir from E.coli'''


==Overview==
Colicin Ia is a 69 kDa protein that kills susceptible Escherichia coli cells by binding to a specific receptor in the outer membrane, colicin I receptor (70 kDa), and subsequently translocating its channel forming domain across the periplasmic space, where it inserts into the inner membrane and forms a voltage-dependent ion channel. We determined crystal structures of colicin I receptor alone and in complex with the receptor binding domain of colicin Ia. The receptor undergoes large and unusual conformational changes upon colicin binding, opening at the cell surface and positioning the receptor binding domain of colicin Ia directly above it. We modelled the interaction with full-length colicin Ia to show that the channel forming domain is initially positioned 150 A above the cell surface. Functional data using full-length colicin Ia show that colicin I receptor is necessary for cell surface binding, and suggest that the receptor participates in translocation of colicin Ia across the outer membrane.

==About this Structure==
2HDF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDF OCA]. 

==Reference==
Structure of colicin I receptor bound to the R-domain of colicin Ia: implications for protein import., Buchanan SK, Lukacik P, Grizot S, Ghirlando R, Ali MM, Barnard TJ, Jakes KS, Kienker PK, Esser L, EMBO J. 2007 May 16;26(10):2594-604. Epub 2007 Apr 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17464289 17464289]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Buchanan, S K.]]
[[Category: Esser, L.]]
[[Category: Lukacik, P.]]
[[Category: Colicin i receptor]]
[[Category: Iron transport]]
[[Category: Membrane protein]]
[[Category: Outer membrane]]
[[Category: Signal transduction]]
[[Category: Tonb box]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:09:03 2008''