View source for 2nx5

[[Image:2nx5.gif|left|200px]]<br />
<applet load="2nx5" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2nx5, resolution 2.700&Aring;" />
'''Crystal structure of ELS4 TCR bound to HLA-B*3508 presenting EBV peptide EPLPQGQLTAY at 1.7A'''<br />

==Overview==
Plasticity of the T cell receptor (TCR) is a hallmark of major, histocompatibility complex (MHC)-restricted T cell recognition. However, it is unclear whether interactions of TCR and peptide-MHC class I (pMHCI), always conform to this paradigm. Here we describe the structure of a TCR, ELS4, in its non-ligand-bound form and in complex with a prominent, 'bulged' Epstein-Barr virus peptide bound to HLA-B(*)3501. This complex, was atypical of previously characterized TCR-pMHCI interactions in that a, rigid face of the TCR crumpled the bulged antigenic determinant. This, peptide 'bulldozing' created a more featureless pMHCI determinant, allowing the TCR to maximize MHC class I contacts essential for MHC class, I restriction of TCR recognition. Our findings represent a mechanism of, antigen recognition whereby the plasticity of the T cell response is, dictated mainly by adjustments in the MHC-bound peptide.

==Disease==
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142830 142830]], Hypoproteinemia, hypercatabolic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109700 109700]], Spondyloarthropathy, susceptibility to, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142830 142830]], Stevens-Johnson syndrome, carbamazepine-induced, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142830 142830]]

==About this Structure==
2NX5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2NX5 OCA]. 

==Reference==
A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule., Tynan FE, Reid HH, Kjer-Nielsen L, Miles JJ, Wilce MC, Kostenko L, Borg NA, Williamson NA, Beddoe T, Purcell AW, Burrows SR, McCluskey J, Rossjohn J, Nat Immunol. 2007 Mar;8(3):268-76. Epub 2007 Jan 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17259989 17259989]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Reid, H.H.]]
[[Category: Rossjohn, J.]]
[[Category: Tynan, F.E.]]
[[Category: immune complex]]
[[Category: tcr-pmhc]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:03:35 2007''