View source for 2erm

[[Image:2erm.jpg|left|200px]]

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{{STRUCTURE_2erm|  PDB=2erm  |  SCENE=  }} 

'''Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue'''


==Overview==
The 3D structure of a complex formed by the acidic fibroblast growth factor (FGF-1) and a specifically designed synthetic heparin hexasaccharide has been determined by NMR spectroscopy. This hexasaccharide can substitute natural heparins in FGF-1 mitogenesis assays, in spite of not inducing any apparent dimerization of the growth factor. The use of this well defined synthetic heparin analogue has allowed us to perform a detailed NMR structural analysis of the heparin-FGF interaction, overcoming the limitations of NMR to deal with the high molecular mass and heterogeneity of the FGF-1 oligomers formed in the presence of natural heparin fragments. Our results confirm that glycosaminoglycans induced FGF-1 dimerization either in a cis or trans disposition with respect to the heparin chain is not an absolute requirement for biological activity.

==About this Structure==
2ERM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERM OCA]. 

==Reference==
Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue., Canales A, Lozano R, Lopez-Mendez B, Angulo J, Ojeda R, Nieto PM, Martin-Lomas M, Gimenez-Gallego G, Jimenez-Barbero J, FEBS J. 2006 Oct;273(20):4716-27. Epub 2006 Sep 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16995857 16995857]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Canales, A.]]
[[Category: Gimenez-Gallego, G.]]
[[Category: Jimenez-Barbero, J.]]
[[Category: Lozano, R.]]
[[Category: Martin-Lomas, M.]]
[[Category: Nieto, P M.]]
[[Category: Fibroblast growth factor]]
[[Category: Heparin-like hexasaccharide]]
[[Category: Protein-carbohydrate complex]]
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