View source for 2dw1

[[Image:2dw1.jpg|left|200px]]

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{{STRUCTURE_2dw1|  PDB=2dw1  |  SCENE=  }} 

'''Crystal structure of VAP2 from Crotalus atrox venom (Form 2-2 crystal)'''


==Overview==
Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. The overall structures show good agreement with both monomers of atypical homodimeric VAP1. Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins.

==About this Structure==
2DW1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DW1 OCA]. 

==Reference==
Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins., Igarashi T, Araki S, Mori H, Takeda S, FEBS Lett. 2007 May 29;581(13):2416-22. Epub 2007 Apr 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17485084 17485084]
[[Category: Crotalus atrox]]
[[Category: Single protein]]
[[Category: Araki, S.]]
[[Category: Igarashi, T.]]
[[Category: Takeda, S.]]
[[Category: Apoptotic toxin]]
[[Category: Metalloproteinase]]
[[Category: Svmp]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 01:29:55 2008''