View source for 2bpy

[[Image:2bpy.jpg|left|200px]]

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{{STRUCTURE_2bpy|  PDB=2bpy  |  SCENE=  }} 

'''HIV-1 PROTEASE-INHIBITOR COMPLEX'''


==Overview==
The ability to replace an inhibitor bound to the HIV-1 protease in single crystals with other potent inhibitors offers the possibility of investigating a series of protease inhibitors rapidly and conveniently with the use of X-ray crystallography. This approach affords a fast turnaround of structural information for iterative rational drug designs and obviates the need for studying the complex structures by co-crystallization. The replacement approach has been successfully used with single crystals of the HIV-1 protease complexed with a weak inhibitor. The structures of the complexes obtained by the replacement method are similar to those determined by co-crystallization.

==About this Structure==
2BPY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPY OCA]. 

==Reference==
Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme., Munshi S, Chen Z, Li Y, Olsen DB, Fraley ME, Hungate RW, Kuo LC, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1053-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9757136 9757136]
[[Category: Deleted entry]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Single protein]]
[[Category: Chen, Z.]]
[[Category: Munshi, S.]]
[[Category: Acid protease]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:37:54 2008''