View source for 2eva

[[Image:2eva.gif|left|200px]]<br />
<applet load="2eva" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2eva, resolution 2.0&Aring;" />
'''Structural Basis for the Interaction of TAK1 Kinase with its Activating Protein TAB1'''<br />

==Overview==
Transforming growth factor-beta (TGF-beta)-activated kinase 1 (TAK1) is a, member of the MAPKKK family of protein kinases, and is involved in, intracellular signalling pathways stimulated by transforming growth factor, beta, interleukin-1 and tumour necrosis factor-alpha. TAK1 is known to, rely upon an additional protein, TAK1-binding protein 1 (TAB1), for, complete activation. However, the molecular basis for this activation has, yet to be elucidated. We have solved the crystal structure of a novel TAK1, chimeric protein and these data give insight into how TAK1 is activated by, TAB1. Our results reveal a novel binding pocket on the TAK1 kinase domain, whose shape complements that of a unique alpha-helix in the TAK1 binding, domain of TAB1, providing the basis for an intimate hydrophobic, association between the protein activator and its target.

==About this Structure==
2EVA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ADN as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2EVA OCA]. 

==Reference==
Structural basis for the interaction of TAK1 kinase with its activating protein TAB1., Brown K, Vial SC, Dedi N, Long JM, Dunster NJ, Cheetham GM, J Mol Biol. 2005 Dec 16;354(5):1013-20. Epub 2005 Nov 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16289117 16289117]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Single protein]]
[[Category: Brown, K.]]
[[Category: Cheetham, G.M.]]
[[Category: Dedi, N.]]
[[Category: Dunster, N.J.]]
[[Category: Long, J.M.]]
[[Category: Vial, S.C.]]
[[Category: ADN]]
[[Category: kinase]]
[[Category: tab1]]
[[Category: tak1]]

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