View source for 2are

[[Image:2are.gif|left|200px]]

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{{STRUCTURE_2are|  PDB=2are  |  SCENE=  }} 

'''Pterocarpus angolensis Lectin (PAL) In Complex With D-Mannose (anomeric mixture)'''


==Overview==
The crystal structure of Pterocarpus angolensis lectin is determined in its ligand-free state, in complex with the fucosylated biantennary complex type decasaccharide NA2F, and in complex with a series of smaller oligosaccharide constituents of NA2F. These results together with thermodynamic binding data indicate that the complete oligosaccharide binding site of the lectin consists of five subsites allowing the specific recognition of the pentasaccharide GlcNAc beta(1-2)Man alpha(1-3)[GlcNAc beta(1-2)Man alpha(1-6)]Man. The mannose on the 1-6 arm occupies the monosaccharide binding site while the GlcNAc residue on this arm occupies a subsite that is almost identical to that of concanavalin A (con A). The core mannose and the GlcNAc beta(1-2)Man moiety on the 1-3 arm on the other hand occupy a series of subsites distinct from those of con A.

==About this Structure==
2ARE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARE OCA]. 

==Reference==
Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin., Buts L, Garcia-Pino A, Imberty A, Amiot N, Boons GJ, Beeckmans S, Versees W, Wyns L, Loris R, FEBS J. 2006 Jun;273(11):2407-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16704415 16704415]
[[Category: Pterocarpus angolensis]]
[[Category: Single protein]]
[[Category: Amiot, N.]]
[[Category: Beeckmans, S.]]
[[Category: Boons, G J.]]
[[Category: Buts, L.]]
[[Category: Garcia-Pino, A.]]
[[Category: Imberty, A.]]
[[Category: Lah, J.]]
[[Category: Loris, R.]]
[[Category: Versees, W.]]
[[Category: Wyns, L.]]
[[Category: Carbohydrate recognition]]
[[Category: Lectin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:23:00 2008''