View source for 1zpb

[[Image:1zpb.gif|left|200px]]

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{{STRUCTURE_1zpb|  PDB=1zpb  |  SCENE=  }} 

'''Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 4-Methyl-pentanoic acid {1-[4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-methyl-propyl}-amide'''


==Overview==
Using an alpha-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort to develop smaller, less peptidic inhibitors as antithrombotic agents.

==Disease==
Known disease associated with this structure: Factor XI deficiency, autosomal dominant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=264900 264900]], Factor XI deficiency, autosomal recessive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=264900 264900]]

==About this Structure==
1ZPB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPB OCA]. 

==Reference==
Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine., Deng H, Bannister TD, Jin L, Babine RE, Quinn J, Nagafuji P, Celatka CA, Lin J, Lazarova TI, Rynkiewicz MJ, Bibbins F, Pandey P, Gorga J, Meyers HV, Abdel-Meguid SS, Strickler JE, Bioorg Med Chem Lett. 2006 Jun 1;16(11):3049-54. Epub 2006 Mar 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16524727 16524727]
[[Category: Coagulation factor XIa]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Abdel-Meguid, S S.]]
[[Category: Babine, R E.]]
[[Category: Bannister, T D.]]
[[Category: Bibbins, F.]]
[[Category: Celatka, C A.]]
[[Category: Deng, H.]]
[[Category: Gorga, J.]]
[[Category: Jin, L.]]
[[Category: Lazarova, T I.]]
[[Category: Lin, J.]]
[[Category: Meyers, H V.]]
[[Category: Nagafuji, P.]]
[[Category: Pandey, P.]]
[[Category: Quinn, J.]]
[[Category: Rynkiewicz, M J.]]
[[Category: Strickler, J E.]]
[[Category: Fxi]]
[[Category: Inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:54:33 2008''