View source for 2d10

[[Image:2d10.gif|left|200px]]<br />
<applet load="2d10" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2d10, resolution 2.50&Aring;" />
'''Crystal structure of the Radixin FERM domain complexed with the NHERF-1 C-terminal tail peptide'''<br />

==Overview==
The Na+/H+ exchanger regulatory factor (NHERF) is a key adaptor protein, involved in the anchoring of ion channels and receptors to the actin, cytoskeleton through binding to ERM (ezrin/radixin/moesin) proteins. NHERF, binds the FERM domain of ERM proteins, although NHERF has no signature, Motif-1 sequence for FERM binding found in adhesion molecules. The crystal, structures of the radixin FERM domain complexed with the NHERF-1 and, NHERF-2 C-terminal peptides revealed a peptide binding site of the FERM, domain specific for the 13 residue motif MDWxxxxx(L/I)Fxx(L/F) (Motif-2), which is distinct from Motif-1. This Motif-2 forms an amphipathic alpha, helix for hydrophobic docking to subdomain C of the FERM domain. This, docking causes induced-fit conformational changes in subdomain C and, affects binding to adhesion molecule peptides, while the two binding sites, are not overlapped. Our studies provide structural paradigms for versatile, ERM linkages between membrane proteins and the cytoskeleton.

==About this Structure==
2D10 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2D10 OCA]. 

==Reference==
Structural basis for NHERF recognition by ERM proteins., Terawaki S, Maesaki R, Hakoshima T, Structure. 2006 Apr;14(4):777-89. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16615918 16615918]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Hakoshima, T.]]
[[Category: Maesaki, R.]]
[[Category: Terawaki, S.]]
[[Category: protein-peptide complex]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:25:12 2007''