View source for 1zbd

[[Image:1zbd.gif|left|200px]]

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{{STRUCTURE_1zbd|  PDB=1zbd  |  SCENE=  }} 

'''STRUCTURAL BASIS OF RAB EFFECTOR SPECIFICITY: CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAB3A COMPLEXED WITH THE EFFECTOR DOMAIN OF RABPHILIN-3A'''


==Overview==
The small G protein Rab3A plays an important role in the regulation of neurotransmitter release. The crystal structure of activated Rab3A/GTP/Mg2+ bound to the effector domain of rabphilin-3A was solved to 2.6 A resolution. Rabphilin-3A contacts Rab3A in two distinct areas. The first interface involves the Rab3A switch I and switch II regions, which are sensitive to the nucleotide-binding state of Rab3A. The second interface consists of a deep pocket in Rab3A that interacts with a SGAWFF structural element of rabphilin-3A. Sequence and structure analysis, and biochemical data suggest that this pocket, or Rab complementarity-determining region (RabCDR), establishes a specific interaction between each Rab protein and its effectors. RabCDRs could be major determinants of effector specificity during vesicle trafficking and fusion.

==About this Structure==
1ZBD is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZBD OCA]. 

==Reference==
Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A., Ostermeier C, Brunger AT, Cell. 1999 Feb 5;96(3):363-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10025402 10025402]
[[Category: Protein complex]]
[[Category: Rattus norvegicus]]
[[Category: Brunger, A T.]]
[[Category: Ostermeier, C.]]
[[Category: Effector]]
[[Category: G protein]]
[[Category: Rab protein]]
[[Category: Rab3a]]
[[Category: Rabcdr]]
[[Category: Rabphilin]]
[[Category: Synaptic exocytosis]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:25:01 2008''