View source for 2bid

[[Image:2bid.gif|left|200px]]<br />
<applet load="2bid" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2bid" />
'''HUMAN PRO-APOPTOTIC PROTEIN BID'''<br />

==Overview==
We report the solution structure of BID, an intracellular cross-talk agent, that can amplify FAS/TNF apoptotic signal through the mitochondria death, pathway after Caspase 8 cleavage. BID contains eight alpha helices where, two central hydrophobic helices are surrounded by six amphipathic ones., The fold resembles poreforming bacterial toxins and shows similarity to, BCL-XL although sequence homology to BCL-XL is limited to the 16-residue, BH3 domain. Furthermore, we modeled a complex of BCL-XL and BID by, aligning the BID and BAK BH3 motifs in the known BCL-XL-BAK BH3 complex., Additionally, we show that the overall structure of BID is preserved after, cleavage by Caspase 8. We propose that BID has both BH3 domain-dependent, and -independent modes of action in inducing mitochondrial damage.

==About this Structure==
2BID is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BID OCA]. 

==Reference==
Solution structure of BID, an intracellular amplifier of apoptotic signaling., Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G, Cell. 1999 Mar 5;96(5):615-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10089877 10089877]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Chou, J.J.]]
[[Category: Li, H.]]
[[Category: Salvesen, G.S.]]
[[Category: Wagner, G.]]
[[Category: Yuan, J.]]
[[Category: apoptosis regulation and amplification]]
[[Category: programmed cell death]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:02:49 2007''