View source for 2bck

[[Image:2bck.gif|left|200px]]<br />
<applet load="2bck" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2bck, resolution 2.800&Aring;" />
'''Crystal Structure of HLA-A*2402 Complexed with a telomerase peptide'''<br />

==Overview==
HLA-A*2402 is the most commonly expressed HLA allele in oriental, populations. It is also widely expressed in the Caucasian population, making it one of, if not the most abundant HLA I types. In order to study, its structure in terms of overall fold and peptide presentation, a soluble, form of this HLA I (alpha1, alpha2, alpha3 and beta(2)m domains) has been, expressed, refolded and crystallized in complex with a cancer-related, telomerase peptide (VYGFVRACL), and its structure has been solved to 2.8 A, resolution. The overall structure of HLA-A*2402 is virtually identical to, other reported peptide-HLA I structures. However, there are distinct, features observable from this structure at the HLA I peptide binding, pockets. The size and depth of pocket B makes it highly suitable for, binding to large aromatic side chains, which explains the high prevalence, of tyrosine at peptide position 2. Also, for HLA binding at peptide, position 5, there is an additional anchor point, which allows the proximal, amino acids to protrude out, providing a prominent feature for TCR, interaction. Finally, pocket F allows the anchor residue at position 9 to, be bound unusually deeply within the HLA structure.

==Disease==
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]], Ankylosing spondylitis, susceptibility to, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]], Aplastic anemia, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=187270 187270]], Dyskeratosis congenita OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=187270 187270]], Hypoproteinemia, hypercatabolic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109700 109700]], Pulmonary fibrosis,idiopathic, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=187270 187270]], Stevens-Johnson syndrome, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]]

==About this Structure==
2BCK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BCK OCA]. 

==Reference==
Crystal structure of HLA-A*2402 complexed with a telomerase peptide., Cole DK, Rizkallah PJ, Gao F, Watson NI, Boulter JM, Bell JI, Sami M, Gao GF, Jakobsen BK, Eur J Immunol. 2006 Jan;36(1):170-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16323248 16323248]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: RNA-directed DNA polymerase]]
[[Category: Cole, D.K.]]
[[Category: Gao, G.F.]]
[[Category: Jakobsen, B.K.]]
[[Category: Rizkallah, P.J.]]
[[Category: GOL]]
[[Category: SO4]]
[[Category: beta barrels]]
[[Category: immunoglobulin domains]]
[[Category: mhc fold]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:00:57 2007''