View source for 1xcu

[[Image:1xcu.gif|left|200px]]

<!--
The line below this paragraph, containing "STRUCTURE_1xcu", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet) 
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_1xcu|  PDB=1xcu  |  SCENE=  }} 

'''oligonucleotid/drug complex'''


==Overview==
The crystal structures of the hexamer duplex d(CGTACG)(2) complexed with the intercalating anthraquinone derivative 1,5-bis[3-(diethylamino)propionamido]anthracene-9,10-dione and the acridine derivative 9-acridinyl tetralysine have been solved at 2.0- and 1.4-A resolution, respectively. In both cases, the drugs adopt multiple orientations within a large DNA cavity constituted by two groups of four approximately coplanar bases. Cations play a pivotal role in the crystal structure. Both complexes crystallise in the presence of Co(2+), Ba(2+) and Na(+) ions. They reveal at least two different types of coordination environments: (1) specific sites for Co(2+) interacting with N7 of guanine; (2) a central ionic site formed by four phosphate groups, which can be occupied by different ions. One more ionic site that is not always occupied by ions is also visible in the electron density map. All of them play a role in the crystal structure.

==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCU OCA]. 

==Reference==
Variable role of ions in two drug intercalation complexes of DNA., Valls N, Steiner RA, Wright G, Murshudov GN, Subirana JA, J Biol Inorg Chem. 2005 Aug;10(5):476-82. Epub 2005 Sep 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15926069 15926069]
[[Category: Murshudov, G N.]]
[[Category: Steiner, R A.]]
[[Category: Subirana, J A.]]
[[Category: Valls, N.]]
[[Category: Wright, G.]]
[[Category: Anthraquinone]]
[[Category: Co2+]]
[[Category: Drug-dna complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:51:59 2008''