View source for 1wlh

[[Image:1wlh.jpg|left|200px]]

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{{STRUCTURE_1wlh|  PDB=1wlh  |  SCENE=  }} 

'''Molecular structure of the rod domain of Dictyostelium filamin'''


==Overview==
Dictyostelium discoideum filamin (ddFLN) is a two-chain F-actin crosslinking protein with an N-terminal actin-binding domain and a rod domain constructed from six tandem repeats of a 100 residue motif that has an immunoglobulin (Ig) fold. We report the 2.8 A resolution crystal structure of a homodimer of rod repeats 4, 5 and 6. The two chains are arranged in an antiparallel fashion and form an elongated element, which is shortened, however, compared to a fully extended, linear configuration because the long axis of each Ig domain is arranged at an angle to the long axis of the rod. Same arrangement of repeats should also be present in the rod domain of human FLNa, much longer than Dictyostelium FLN, which forms an extended structure able to crosslink F-actin chains over distances of more than 1000 A.

==About this Structure==
1WLH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WLH OCA]. 

==Reference==
Molecular structure of the rod domain of dictyostelium filamin., Popowicz GM, Muller R, Noegel AA, Schleicher M, Huber R, Holak TA, J Mol Biol. 2004 Oct 1;342(5):1637-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15364587 15364587]
[[Category: Dictyostelium discoideum]]
[[Category: Single protein]]
[[Category: Holak, T A.]]
[[Category: Huber, R.]]
[[Category: Mueller, R.]]
[[Category: Noegel, A A.]]
[[Category: Popowicz, G M.]]
[[Category: Schleicher, M.]]
[[Category: Abp-120]]
[[Category: Filamin]]
[[Category: Immunoglobulin fold]]
[[Category: Rod domain]]
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