View source for 1zp5

[[Image:1zp5.gif|left|200px]]<br />
<applet load="1zp5" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1zp5, resolution 1.80&Aring;" />
'''Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor'''<br />

==Overview==
The first crystallographic structure of an N-hydroxyurea inhibitor bound, into the active site of a matrix metalloproteinase is reported. The ligand, and three other analogues were prepared and studied as inhibitors of, MMP-2, MMP-3, and MMP-8. The crystal structure of the complex with MMP-8, shows that the N-hydroxyurea, contrary to the analogous hydroxamate, binds, the catalytic zinc ion in a monodentate rather than bidentate mode and, with high out-of-plane distortion of the amide bonds.

==About this Structure==
1ZP5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA, ZN and 2NI as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ZP5 OCA]. 

==Reference==
N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8., Campestre C, Agamennone M, Tortorella P, Preziuso S, Biasone A, Gavuzzo E, Pochetti G, Mazza F, Hiller O, Tschesche H, Consalvi V, Gallina C, Bioorg Med Chem Lett. 2006 Jan 1;16(1):20-4. Epub 2005 Oct 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16242329 16242329]
[[Category: Homo sapiens]]
[[Category: Neutrophil collagenase]]
[[Category: Single protein]]
[[Category: Agamennone, M.]]
[[Category: Biasone, A.]]
[[Category: Campestre, C.]]
[[Category: Gallina, C.]]
[[Category: Gavuzzo, E.]]
[[Category: Mazza, F.]]
[[Category: Pochetti, G.]]
[[Category: Preziuso, S.]]
[[Category: Tortorella, P.]]
[[Category: Tschesche, H.]]
[[Category: 2NI]]
[[Category: CA]]
[[Category: ZN]]
[[Category: hydrolase]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:38:09 2007''